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The long ORF encodes a polyprotein which is processed co- and posttranslationally by host and viral proteases into at least 10 different proteins, which are arranged in the order of NH 2 -C-E1-E2-p7-NS2-NS3-NS4A-NS4B-NS5A-NS5B-COOH

Rotating injection sites between the abdomen, thigh, and upper arm reduces the likelihood of persistent irritation

Presented for research literature review only Hayes PC et al

10.1161/CIRCRESAHA.108.190611 Circ Res

Candidates typically have a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher accompanied by a weight-related health condition such as hypertension or type 2 diabetes