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Patients should never adjust their dose independently or skip the titration schedule without medical guidance
The problem was the side effects associated, particularly with GLP-1, are what we call peak to trough: so the difference between the highest amount of drug and the lowest and then going back up again to the highest caused by this twice-a-day dosingwhich you can imagine someone bouncing around maybe two to three times, the drug at peak, then trough, causes a lot of GI distress
Some people use it short-term to reach a goal, while others stay on a lower maintenance dose longer to help keep weight off
Exogenous source L-serine can be obtained through dietary intake
Most patients find this tolerable and do not notice any significant pain or discomfort
