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Phase 2 trial in type 2 diabetes (Lancet 2023) also showed superior weight loss for the combination versus either monotherapy
doi: 10.3390/nu11051023 37
Early-phase clinical trial data, including results from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023), demonstrated significant weight reduction in adults with obesity (without type 2 diabetes), with participants receiving the highest dose losing a mean of approximately 24% of their body weight over 48 weeks
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