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Besides, AOD9604 doesnt affect IGF-1 and insulin levels, thus ensuring minimal risk of developing glucose intolerance and diabetes mellitus
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In theory, combining agents that both reduce adiposity and improve insulin sensitivity could produce additive or synergistic metabolic effects but this is entirely speculative and unproven in humans
When NNMT consumes NAD+ faster than it can be replenished, even well-functioning mitochondria can't maintain oxidative phosphorylation at optimal rates
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