Semaglutide Regulatory Status in Canada Health Canada Approval Status (Ozempic, Wegovy, Rybelsus, Generic) Semaglutide is the active ingredient in three Novo Nordisk products authorized for sale in Canada: Ozempic (authorized 2018 for type 2 diabetes, with an expanded indication in 2024 to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes), Rybelsus (oral semaglutide tablets authorized for type 2 diabetes), and Wegovy (authorized 2021 for chronic weight management, with an expanded indication in 2024 to reduce the risk of non-fatal myocardial infarction, and a Notice of Compliance with Conditions issued in December 2025 for non-cirrhotic metabolic dysfunction-associated steatohepatitis with moderate to advanced liver fibrosis)
5a), confirming successful genome editing via LNP-mediated HITI
Adequate calcium intake (1,000-1,200mg daily), vitamin D supplementation (1,000-2,000 IU daily), and weight-bearing exercise during treatment help maintain bone integrity
Overall, semaglutide was associated with a 38% reduction in major adverse cardiovascular event (MACE) risk within three months, and a 41% reduction in MACE risk within six months
We should also note that the first test is often the "tip of the iceberg" - and often on subsequent testing the levels increase since excretion capacity has improved