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Concerns about thyroid cancer with GLP1-RA use were first raised in the premarketing phase after studies showed increased rates of thyroid C cell tumours in rodents (1)

The value of any result depends on material identity, assay conditions, controls and reproducible records

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Compound 2 (5.4 g, 9.72 mmol), H-Lys(Boc)-OMeHCl (3.46 g, 11.52 mmol), HATU (7.42 g, 19.44 mmol) and HOAT (2.64 g, 19.44 mmol) were dissolved in DMF (80 mL) under nitrogen atmosphere and ice bath conditions