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15, 16 Body composition in a subgroup of participants was measured at randomization and week 20 only by dual-energy X-ray absorptiometry and single-slice abdominal computerized axial tomography
Similarly, the GIPR rs1800437 variant affects glucose-dependent insulinotropic peptide signaling, which may improve weight loss response when targeted with dual-action compounds
Patients with certain genetic profiles may experience stronger appetite suppression from semaglutide, while others have more modest effects
It is important to emphasise that these mechanisms remain theoretical in humans, derived largely from animal research and indirect evidence
A saturation binding isotherm for exendin(9-39)-FITC was performed during each experiment, and the K i values for competing agonists were determined using the Fit K i preset of Prism 8.0
