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Most notable is a study of cardiovascular outcomes among 2,287 patients with type 2 diabetes and obesity who underwent bariatric surgery at Cleveland Clinic and 11,435 matched controls ( JAMA
Eating one large high-protein meal per day and nothing else
The trade-offs include unpredictable absorption affected by food intake, stomach pH, and gastrointestinal health conditions like acid reflux or irritable bowel syndrome
This is because semaglutide also slows the emptying of your stomach and suppresses your appetite but is less likely to cause the same results as Wegovy as it comes in a lower dose for blood sugar management
Key References: Nature Medicine (2022): Two-year effects of semaglutide (STEP 5 trial) Diabetologia (2024): Network meta-analysis of GLP-1 and 2
