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The activity and physicochemical properties of the payload have a direct impact on the antitumor efficacy of ADC drugs
This approach not only potentiated apoptosis but also blocked compensatory survival pathways, supporting its potential to overcome resistance in MSS CRC [160]
Mitochondria cannot manufacture glutathione de novo , so glutathione is synthesized in the cytosol and a small fraction of the total cellular pool is then imported into the mitochondrial matrix by carrier-mediated transport (22
The central composite endpoint was the period that starts from randomization to the first occurrence of a MACE or major adverse cardiovascular event such as cardiovascular collapse, non-fatal stroke, and non-fatal myocardial infarction
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