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Clin Endocrinol (Oxf) 57: 577-585 Wekking EM, Appelhof BC, Fliers E, Schene AH, Huyser J, et al

The agreement between both assays at subtype level was 15/16 for subtype 1a (93.8%

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Chronic insulin resistance impairs pancreatic -cell function, reducing insulin production and persistent hyperglycemia

Inhibition of SGLT2 reduces sodium reabsorption in the proximal tubule and enhances Na + delivery to the macula densa, promoting finally the TGF activation with consequent afferent arteriole vasoconstriction and reduction of the single-nephron-glomerular-filtration-rate ( Figure 1 )