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In a new study reported in The Lancet, Tirzepatide, a GLP-1R/GIPR agonist, reduced alcohol's rewarding properties, locomotor stimulation, conditioned place preference, and accumbal dopamine release

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This combination creates blood sugar volatility (spike from sugar, crash from alcohol liver inhibition) and adds hundreds of empty calories that directly undermine your weight loss progress

Doses are increased gradually over time which allows your body to get used to the medication and serves to lessen side effects

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