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doi:10.1016/j.mam.2004.06.006
Additionally, GLP-1 medications are not recommended during pregnancy, and for semaglutide specifically, treatment should be discontinued at least 2 months before a planned pregnancy
It also promotes fluid retention, increases cholesterol levels, and can reduce motivation for physical activity through fatigue and depression
However, several observations do not support general BBB permeability, including the limited brain access observed with fluorescently labeled semaglutide in the present study, together with analogous results with GLP-1 (35) and liraglutide (8)
Side effects and safety profiles Every medication is a trade-off between benefit and harm
