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Injections of micronutrient B12 at larger doses may be necessary for older persons to keep their vitamin levels appropriate

doi: 10.1016/j.amjmed.2014.10.014 218

So if something goes wrong and the GSSG accumulates, it inhibits an enzyme that relies on the correct oxidation of the ER environment to operate a protein quality control system. Moreover, they discovered, when misfolded proteins dont pass quality control, they wont get exported, so they too pile up in the ER

Supplement Considerations for Brain Health If you have a brain disorder or poor cognitive function, its crucial to supply the brain with enough of the building blocks it needs to make glutathione and other antioxidants

Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration