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[118] The tentative approval means that a scientific assessment of the generic drug was completed successfully, and that contracts and supply chains can be established, but that selling the drug would depend on intellectual property constraints

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99 However, knockdown of bromodomain-containing protein 4 (BRD4), an essential member of the bromodomain and extra-terminal domain (BET) family and epigenetic reader, markedly reduces H4K8la level, increasing A1 polarization in astrocytes and promoting neuronal death by pro-inflammatory factors such as IL-6, IL-1, and TNF-

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