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GSDME is highly expressed in normal colon epithelium, and radiation induces GSDME-mediated pyroptotic cell death, resulting in the release of the proinflammatory cytokines IL1, IL6, TNF, and HMGB1, which recruit and activate NK cells, leading to radiotherapy-associated colitis 49
Melatonin ameliorates age-related sarcopenia via the gut-muscle axis mediated by serum lipopolysaccharide and metabolites
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Mechanisms of Action: How Does GHK-Cu Promote Cellular Regeneration
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