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Modulation of Dopaminergic and Serotonergic Systems A growing body of preclinical evidence highlights BPC-157s influence on major neurotransmitter pathways

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13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig

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doi: 10.1016/j.ceb.2025.102595 153 ArdenCParkSHYasasilkaXRLeeEYLeeMS