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This transport mechanism involves: Deposition of oxytocin on olfactory and respiratory epithelia in the upper nasal cavity Extracellular diffusion through perineural clefts and along the cribriform plate Access to olfactory bulbs and deeper rostral brain structures via trigeminal pathways Possible intracellular axonal transport along olfactory sensory neurons This direct route hypothesis remains actively debated, as current evidence confirms increased CSF oxytocin concentrations following intranasal delivery but has not yet established that this rise results exclusively from direct nerve-mediated transport rather than peripheral vascular absorption followed by secondary central release[4]
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