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CORT in colon tissue induces an increase in both GR and GILZ expression, thereby inhibiting NF-B activity and reducing pro-inflammatory cytokine levels such as IL-1 and TNF- (354)

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5H, I), while overexpression of a codon-optimized L2HGDH (L2HGDH OPT ), which is resistant to the designed sgRNA, reverses this effect (Fig