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To reach their full anti-cancer potential, cytotoxic agents like doxorubicin, epirubicin, paclitaxel, docetaxel, cisplatin, carboplatin, antimetabolites, 5-fluorouracil, capecitabine, and targeted therapies like trastuzumab and CDK4/6 inhibitors rely on precise dosing or predictable metabolic pathways, among other factors (201)
doi: 10.1007/s00253-021-11264-4 142 SelisanaS
Researchers should routinely monitor storage conditions to protect sample integrity and experimental consistency
In addition, consistent with the findings reported elsewhere, we found DMF induces the activation of NRF2, and NRF2 targets such as those involved in cystine uptake (SLC7A11) and GSH biosynthesis (GCLM and GCLC, the mediator and catalytic subunits of GCL) (Fig