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Some people do have difficulties ingesting supplements, at which point a higher dosage can be prescribed (up to 10,000 mcg) by your doctor, in order to ensure you are getting the sufficient levels your body needs
The PlexusDx Precision Peptide Genetic Test ($298) examines variants like FTO rs9939609 and MC4R rs17782313 that influence how your body responds to metabolic interventions
When Combination Might Be Considered: In select cases, clinicians might discuss combination therapy for patients who: Have achieved partial but insufficient response to maximally tolerated tirzepatide Have specific dietary patterns with high fat intake Have previously responded well to orlistat but need additional intervention Understand and accept the increased side effect burden For patients with BMI 40 kg/m or 35 kg/m with obesity-related comorbidities, referral for bariatric surgery evaluation should be considered per American Society for Metabolic and Bariatric Surgery guidelines, rather than pursuing multiple pharmacotherapies
Bluemlein, K
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