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Despite broad preclinical support, human data are limited to a small number of low-quality, small-sample-size studies, and no large-scale randomized controlled trials have been published to date [4]

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While semaglutide activates only the GLP-1 receptor and tirzepatide targets both GLP-1 and GIP receptors, retatrutide activates all three metabolic hormone receptors: GLP-1, GIP, and glucagon

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