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Feldstein, E

Physical activity accelerates weight loss and improves metabolic health beyond what medication alone can achieve

Reduced glutathione (GSH) is composed of three amino acids: cysteine, glutamic acid and glycine

Key risk factors include: Rapid weight loss: Losing weight quickly significantly increases gallstone risk Female sex: Women are two to three times more likely to develop gallstones than men Age over 40 years: Gallstone prevalence increases with age Obesity: Higher baseline BMI correlates with increased risk Previous history of gallstones: Prior biliary disease predicts recurrence Family history: Genetic factors contribute to gallstone susceptibility Certain ethnicities: Native American and Hispanic populations have higher baseline rates Estrogen exposure: Oral contraceptives, hormone replacement therapy, and multiple pregnancies Diabetes and dyslipidemia: Metabolic conditions affecting bile composition Prolonged fasting or TPN use: Reduces gallbladder contraction Patients should be educated about warning signs that may indicate gallstone complications

doi: 10.1016/j.bcdf.2024.100401 30