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Subcutaneous injection sites are the abdomen (avoid 2 inches around the navel), the front or outer thigh, or the back of the upper arm
The pills dissolve in the stomach and rely on an absorption enhancer to get through the acid environment
Unlike semaglutide (a large peptide requiring specialized absorption technology), orforglipron is a small molecule that absorbs more reliably through the GI tract, can be taken with food, and is cheaper to manufacture
In theory, this approval opens the door for broader utilization of Wegovy by appealing to individuals who may be wary of injections
Outsized fatigue or feeling cold all the time can be a sign you are under-eating, especially protein, while the medication suppresses your appetite
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