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While the former is generally recommended for patients with uncomplicated obesity, while the latter may be more suitable for individuals with multiple cardiometabolic comorbidities

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While glucagon increases blood glucose levels via stimulating the liver to release glucose, glucagon-like peptide-1 (GLP-1) has pretty much the opposite effect in that it can decrease blood glucose by stimulating more insulin to be released by the beta-cells in the pancreas.[ref] GIP (glucose-dependent insulinotropic peptide) not only acts on the GIP receptor (GIPR) in the pancreas, but it also acts upon other tissues such as fat, bone, and endothelial cells lining blood vessels

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