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Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

Pooled Phase III analysis (n=816) Consistent VAT reductions across both trials with maintenance during continued therapy and regression toward baseline after stopping

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Following two washes, aortic rings were contracted by a stimulation using phenylephrine (10 6 mol/L)