Furthermore, glutathionylated residue C151 of roGFP2 reacted three to four times faster than glutathionylated residue C208, which is again the opposed reactivity as observed for the oxidation kinetics of both monothiol roGFP2 variants (Table 1)
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Release the pinch, then inject slowly
Thus, although GIPR in the AP is required for the weight loss effects of GIPR agonists, it is not the target of therapeutic GIPR antagonists, supporting recent findings that Gipr KO in GABAergic neurons also abolished responses to GIPR agonism but not antagonism 6
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