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Pharmacol Rev 63:134
Long-term low B12 can drive elevated homocysteine and contribute to megaloblastic or pernicious anemia
Concentration: 2.5 mg per mL 1 unit on a U-100 syringe = 0.025 mg (25 mcg) The 0.25 mg dose at 10 units is clean and easy to read
Mechanistic and fibroblast data are robust, but large independent randomized trials comparing GHK-Cu head-to-head with tretinoin are lacking
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