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Firstly, the study was limited to male mice, which may not adequately represent potential sex-based differences in the response to semaglutide treatment
However, a 9-year follow-up study of Finnish male smokers aged 5069 years [51] showed that when compared with weight-stable subjects, subjects with greater weight fluctuations had a significantly increased risk of type 2 diabetes
This depletion is why supplementation has become so popular
It is plausible that a higher dose may have resulted in greater weight loss, but probably also in a greater incidence of adverse effects
GLP-1 drugs show how quickly innovation can outpace policy, how cost pressures are resolved through access restrictions, and how deeply entrenched inequities shape who benefits from medical progress
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