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When the gut lining becomes compromised, it can lead to a wide range of issues including inflammation, poor digestion, and systemic health disruptions
Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)
Some mild side effects, such as stomach issues, were reported, but these were uncommon and did not lead to discontinuation of the treatment
99% is now a category baseline
"F.D.I.C
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