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GLP-1 receptor agonists generally lower blood pressure by 2-6 mm Hg through multiple mechanisms, including weight loss, improved endothelial function, and enhanced natriuresis
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Tirzepatide activates GIP and GLP-1 receptors
In the forest plot, several studies including Harmony Outlets (2018), LEADER (2016), REWIND (2019), and SUSTAIN-6 (2016) appear to show a low risk of respiratory diseases
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