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They may be a better fit if youre targeting more substantial weight loss, have had limited success with previous interventions, prefer a low-maintenance routine with minimal daily decisions, or want to reduce variables related to absorption and timing
argues that intensive weight loss can create a POPdriven toxic rebound that partially undermines cardiometabolic benefits and may promote weight regain by mobilizing lipophilic pollutants from adipose into blood and target organs.3 From this publication, we learn that the abrupt rise in circulating POPs during intensive weight loss can: Disturb energy metabolism (resting metabolic rate/sleeping metabolic rate), oxidative enzymes, thyroid axis) Impair insulin action and mitochondrial function Redistribute POPs from adipose to organs (liver, muscle, pancreas, nervous system), increasing cardiometabolic risk The authors summarize clinical data where intentional weight loss improves body weight and some risk factors, but does not fully normalize, or even worsens glucose tolerance, blood lipids, or inflammatory markers
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