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Specifically, the IGF-1-PI3K-Akt-mTOR cascade promotes protein synthesis and suppresses protein degradation by phosphorylating downstream FoxO, thereby inhibiting E3 ligases (MuRF1 and atrogin-1) (73,81)
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Metabolic adaptation also plays a significant role in post-treatment weight gain
In vitro, in differentiated human DA neurons, IR was associated with increased -synuclein and ROS levels, as well as mitochondrial depolarization, which may be mediated by polo-like kinase-2
They may occur when patients start a GLP-1 agonist or increase their dose, and some can go away on their own over time
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