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The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice
H.ZhangR.LiL.WangY
Tirzepatide, on the other hand, is a dual-agonist that targets both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, showing different signaling dynamics in metabolic models
Published pharmacokinetic data from Aebi et al
Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)
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