Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig
With respect to safety, it is also crucial to thoroughly evaluate the safety profiles and potential adverse effects of HDTs
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Key areas of research: Growth Hormone Research IGF-1 Research Endocrinology Research GHRH Research Ghrelin Receptor Research Metabolic Research Hormonal Signaling Research Healthy Aging Research Pituitary Function Research Growth Hormone Secretagogue Research References CJC-1295, a Long-Acting Growth Hormone-Releasing Hormone Analog Ipamorelin, the First Selective Growth Hormone Secretagogue References are provided for research context only and do not constitute medical claims
