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The New England Journal of Medicine

Its overactivation disrupts nicotinamide metabolism, reduces NAD+ levels, promotes hepatic lipid accumulation and lipotoxicity, and represents an important therapeutic target for hepatic metabolic disorders

When overactive, it lowers NAD+ levels and promotes fat accumulation , particularly in visceral (deep belly) fat

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Originally researched for neurodegenerative conditions, Tesofensine demonstrated a profound impact on body weight and fat mass during clinical trials