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It directly activates adenylyl cyclase in epidermal cells, leading to increased intracellular cyclic adenosine monophosphate (cAMP) levels, which in turn stimulate melanogenesis in melanocytes independent of MC1R function
GSTA1*-69C/T and GSTO2*N142D as Asthma- and Allergy-Related Risk Factors in Italian Adult Patients. Clinical and Experimental Pharmacology & Physiology, vol
Given the ancient origin of the Ca 2+ -based signaling, which evolutionary developed earlier than the mitochondrial apoptotic toolkit whose emergence cannot be dated back to the times earlier than eukaryogenesis and acquisition of an endosymbiotic mitochondrion, it can be assumed that the Ca 2+ toolkit takes over a key role in cell death signaling in terminally differentiated mitochondria-free erythrocytes
2023 Dec 15;382(6676):1226-1227
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