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The OASIS 4 trial, published in 2025, found that the 25-milligram oral dose of semaglutide produced an average weight loss of 13.6% over 68 weeks
For details on how Zepbound compares to other options, see our GLP-1 comparison guides
Food Chem 30(299):125124 Wang D, Bu T, Li Y, He Y, Yang F, Zou L (2022) Pharmacological activity, pharmacokinetics, and clinical research progress of puerarin
Pregnancy and breastfeeding are also contraindicated due to a lack of safety data for systemic use in these populations
They were also less likely to experience a documented opioid poisoning event over the study window, with 7% having such an event, versus 16% for those without a prescription (see Figure below)
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