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Their findings demonstrated that oral SPE supplementation significantly ameliorated RGC loss and visual dysfunction in a dose-dependent manner

Specific transport proteins are required to mediate folate transfer across cell membranes, either during intestinal absorption or distribution into tissues

doi: 10.3389/fcell.2025.1698296 Received 03 September 2025 Revised 02 December 2025 Accepted 04 December 2025 Published 08 January 2026 Volume 13 - 2025 Edited by Dongxu Wang, Jiangsu University of Science and Technology, China Reviewed by Mohamed Taha Moutaoufik, Mohammed VI Polytechnic University, Morocco Sudipta Ashe, Minutia Inc., United States Updates Copyright 2026 Ruchko, Chernysheva, Sokolov, Starinnov, Sabirov and Vasiliev

Retrieved 22 July 2016

Cohen himself tried to develop it as a drug, but the peptide was so unstable that it broke down within minutes