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The S100A15 gene has an alternative splicing site and two mRNA isoforms, i.e., the long isoform S100A15-L (104 amino acids) and the short isoform S100A15-S (101 amino acids) with exon 1 being spliced out (10, 90, 169)

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Blood draw timing relative to dose administration is a critical variable in these study designs, since GH pulses are short-lived and can be missed entirely if sampling intervals are too widely spaced

Treatment protocols are individualized and monitored under provider supervision to ensure safety, tolerability, and appropriate clinical oversight