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Plasma from xCT-knockout mice contains a higher proportion of oxidised cysteine 179 and xCT expression is increased in many tumours, 180 pointing out its relevance in the context of cancer and eventually contributing for cancer metabolic rewiring

Additionally, endothelial dysfunction may also lead to vascular-ventricular uncoupling and afterload mismatch, collectively implying a causal role of aging in HFpEF pathogenesis

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A lowering over time or oxidization of glutathione is natural