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Introducing cleavable linkages into optimized systems often alters activity profiles, while chemical building blocks used in conjugations may prove incompatible with the intricacies of biological systems, leading to discouraging outcomes in clinical trials
30 , 157173.e157 (2019)
10.1371/journal.pone.0085984 112 KrugerC.SchallreuterK
The peptide has also been associated with normalised NO signaling under both excessive and suppressed NO states, counteracting the implications of NOS blockade and NO overproduction
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