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Many would argue that while there is no gold-standard clinical trial evidence that GLP-1s work alone to make people lose weight because they have all been tested in conjunction with lifestyle interventions such as healthy diet and exercise there is plenty of real world evidence that they do
References: Perspectives into the experience of successful, substantial long-term weight-loss maintenance: a systematic review
These arent isolated incidents
Gastroinstestinal problems were again the most commonly experienced side-effects in those taking semaglutide with around 6% of the studys participants stopping the trial because of these side-effects
TR: 7.0 ms
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