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For instance, the phentermine-topiramate combination increases anxiety and depression

It is typically administered via subcutaneous injection in a titrated daily dose, carefully increasing over several weeks to achieve desired tanning effects while minimizing side effects

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JAMA 298:194206 Phung OJ, Scholle JM, Talwar M, Coleman CI (2010) Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes