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Attention was focused on the effect of ascorbate on chemotherapy or the effect of ascorbate in mitigating the side effects of chemotherapy (Du et al

For example, in pulmonary MVECs exposed to chronic IH, ROS production increased and was associated with endothelial barrier dysfunction due to ROS-dependent activation of extracellular signal-regulated kinases (ERK) 1/2 and c-Jun N-terminal kinases that initiate the reorganization of cytoskeletal and junctional proteins [154]

Whether it adds measurable benefit in combination has not been studied

[8] Pal-GHK and Skin Repair Studies have explored the potential of the amino acid sequence GHK in enhancing skin tissue recovery in laboratory settings

This synergy is often explored in protocols for musculoskeletal and tissue regeneration research