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UV radiation (UVR) exposure can activate the cutaneous immune system by releasing pro-inflammatory factors, ROS, and inducing apoptosis in keratinocytes, thereby causing sterile inflammation or cancer (Tang et al., 2021)

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Dysbiosis, or microbial imbalance, exacerbates chronic inflammation and disrupts tissue regeneration

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In the mouse model after 9 Gy TBI, the release of microRNAs (miRNAs) via exosomes worsened intestinal injury by promoting apoptosis and DNA damage of intestinal cells (54)