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Diabetes Technol Ther (2020) 22(1):108
33.4 pM for GIP) but approximately 13-fold weaker potency than GLP-1 in activating GLP-1R (EC50 = 934 pM for tirzepatide vs.70.5 pM for GLP-1)
mild, transient hypoglycemia may occur, especially when fasting
This triple mechanism produces greater weight loss, potentially better metabolic improvements, and additional effects like increased energy expenditure from glucagon activation
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