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Beyond individual trials, a series of recent systematic reviews and meta-analyses provides converging evidence on the magnitude, timing, and determinants of post-discontinuation weight regain
Satiety matters
Heres where the hormonal interaction becomes practically important: if weight loss on GLP-1 therapy improves ovulatory function, particularly in women with PCOS or obesity-related anovulation, fertility may increase during treatment even if cycles were previously irregular or absent
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Given that GCL or GGT pharmacological inhibition or silencing effectively blocks the growth of lymphoid tumor cells in 3D gels, including TIC-like cells, we propose that high glutathione levels in the minority of tumor cells that thrive in 3D gels counteract ROS-induced cell death
