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What the evidence says is that in the STEP 1 extension, participants regained roughly two-thirds of their lost weight within a year of stopping, which is why many providers now frame goal weight as the beginning of a maintenance phase rather than the end of treatment
[32] In an exome-wide meta-analysis across three cohorts (UKB, GHS and MCPS), there were 16 genes for which there genetic variants was associated with BMI
Curr Mol Med (2013) 13:2457
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