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TRANSCEND-T2D-1 also reported improvements in non-HDL cholesterol, triglycerides, and systolic blood pressure, but these are risk markers rather than proof of fewer heart attacks, strokes, kidney outcomes, or heart failure events [9]

Because the FDA regards human feces as an unapproved drug, fecal microbiota transplants require FDA approval under their Investigational New Drug program, except in cases of recurrent bowel infection due to the bacterium Clostridium difficile (Moore 2014)

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LDL cholesterol reduction was greater in the semaglutide group, although mean LDL levels remained above recommended targets for high-risk individuals with T2D