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Lipid homeostasis abnormalities are pathological features of many diseases, such as metabolic syndrome, obesity, diabetes, fatty liver, cardiovascular disease, and cancer [261]

When combined with semaglutide 2.4mg in the REDEFINE program, participants achieved substantially greater weight loss compared to either agent alone positioning the combination as a potential cornerstone of pharmacological obesity treatment

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In contrast, more than 80% of those starting SGLT2 or insulin added another medication